In the event of new or worsening GI symptoms, perform a prompt diagnostic evaluation and treat appropriately. Embryo-fetal toxicity: Based on the mechanism of action and findings in animals, ADCETRIS can cause fetal harm when administered to a pregnant woman. Females of reproductive potential should avoid pregnancy during ADCETRIS treatment and for at least 6 months after the final dose of ADCETRIS. Adverse Reactions In two uncontrolled single-arm trials of ADCETRIS as monotherapy in 160 patients with relapsed classical HL and sALCL, the most common adverse reactions (20%), regardless of causality, were: neutropenia, peripheral sensory neuropathy, fatigue, nausea, anemia, upper respiratory tract infection, diarrhea, pyrexia, rash, thrombocytopenia, cough and vomiting. In a placebo-controlled trial of ADCETRIS in 329 patients with classical HL at high risk of relapse or progression post-auto-HSCT, the most common adverse reactions (20%) in the ADCETRIS-treatment arm (167 patients), regardless of causality, were: neutropenia, peripheral sensory neuropathy, thrombocytopenia, anemia, upper respiratory tract infection, fatigue, peripheral motor neuropathy, nausea, cough, and diarrhea. Drug Interactions Concomitant use of strong CYP3A4 inhibitors or inducers, or P-gp inhibitors, has the potential to affect the exposure to monomethyl auristatin E (MMAE). Use in Specific Populations MMAE exposure and adverse reactions are increased in patients with moderate or severe hepatic impairment or severe renal impairment. Avoid use. Advise females of reproductive potential to avoid pregnancy during ADCETRIS treatment and for at least 6 months after the final dose of ADCETRIS.
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<img src="http://cbsnews1.cbsistatic.com/hub/i/r/2016/11/29/c8a52a3d-affb-4470-8456-3072e5eccc52/thumbnail/380×240/664f505b994b05f50eb688be169bf6a9/1128-cbsn-mcs-cyberdecember-1188232-640×360.jpg" width='250px' alt='How "Cyber Monday" deals Learn More could last all month’ align=’left’ /> Discounts for rival Walmarts ( WMT ) similarly promoted items rose from read what he said 28 percent to 33 percent, according to Boomerang. Smaller retailers are also getting in on the markdown action. Urban Outfitters ( URBN ) had a buy-one-get-one-50-percent-off offer at its flagship stores for all apparel during the Thanksgiving holiday period, according to a client note from Wedbush Securities. The trendy retailer had discounts of 30 percent to 40 percent last year on items that were on clearance. Millions of Americans are doing their holiday shopping online. And these major online deals may extend past go to web the website just “Cyber Monday.” Hitha Herzog joi… At Coachs ( COH ) Thanksgiving Sale, consumers could get 30 percent off, whereas last year the discounts varied depending on what they spent. L Brands ( LB ) Victoria Secrets generated strong traffic with lines out the door at many locations with its 50-percent-off deal on certain bras, Wedbush said. Last year, customers of the lingerie chain had to buy one bra to get another half off. Its more promotional than last year, said Boomerang CEO Guru Hariharan, a former Amazon ( AMZN ) and eBay ( EBAY ) executive.
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